We are looking for a passionate, intellectually curious, and creative postdoctoral research associate with a strong interest in stem cells and tissue regeneration to join our lab.
The Patel lab at the School of Cellular and Molecular Medicine, University of Bristol studies how tissues regenerate themselves after damage.
To better understand this process, we use the adult Drosophila intestine (or midgut), which has many similarities to our own intestine. Upon injury, the adult fly midgut regenerates itself by replacing damaged and lost cells via rapid intestinal stem cell (ISC) proliferation. One potential mechanism that may govern how midguts sense and respond to tissue damage is the production of reactive oxygen species (ROS), which have been shown to play an essential role in whole body, appendage, and tissue regeneration in various organisms. Likewise, in adult fly midguts, ROS production also promotes ISC-mediated regeneration. Damage activates ROS-mediated Ask1-p38 stress signalling activation in enterocytes, which in turn stimulates production of an ISC mitogen (Patel et al., 2019; Nat. Commun., PMID: 31554796). This mechanism, however, only partially accounts for how ROS promote midgut regeneration.
We are now using genetics, transcriptomics, light microscopy and flow cytometry to further determine how damaged midguts respond to ROS and how ROS promote adult fly midgut regeneration. You will also have the opportunity to translate your findings to mammals using mouse tissues and organoids. We aim for our work to have far-reaching impact on our understanding of regeneration in many contexts and to help develop therapies for tissue regeneration, inflammatory diseases and cancer.
Our lab is generously funded by the Wellcome Trust, and you will have access to top-notch core facilities for your work, travel funds to attend conferences and access to staff development courses.
Applicants should have a PhD (awarded or soon to be awarded) in cell or developmental biology or in a related subject. Expertise with Drosophila, molecular biology and microscopy is a plus but not essential.
To apply, please send your CV and cover letter to Dr Parthive Patel at [email protected]. Your cover letter should describe a) your most important research contributions, b) why your research is important and what impact it has had, c) your research interests and career aspirations and d) why you think our lab is the best environment for your career development.
The full-time appointment is available immediately (flexible start) and will be initially for 2 years with the possibility of an extension for 1 or more years.
Non-UK candidates will be supported to obtain endorsement for a Global Talent Visa. Information about reimbursement of immigration and relocation costs can be found at: http://www.bristol.ac.uk/jobs/relocation-support. The grant will cover the Immigration Health Surcharge associated with applying for a visa.
We welcome applications from around the world and from under-represented individuals in science.
Starting salary: 35,333-44,737 GBP. We also offer a generous pension scheme and value flexible working.
For more information, please visit www.gutstresslab.org. Find us on Twitter @gutstresslab.
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