Details
This PhD studentship presents a pioneering exploration in the intersection of nanotechnology and neuroscience, focusing on neuronal cell behaviour using quantum dot metrology. The project aims to advance our understanding of neuronal cell recovery processes following a stroke and/or development of post-stroke pain, with the ultimate goal to develop novel therapeutic approaches.
Background:
Post-stroke recovery is marked by complex cellular changes, including excitotoxicity, inflammation, and cell death pathways, often leading to chronic pain in survivors. Therapeutic hypothermia has emerged as a promising treatment, reducing neurological damage by lowering brain temperature. This project seeks to refine these neuroprotective strategies through innovative metrology methods.
Research Novelty:
The project leverages the unique properties of semiconductor quantum dots, renowned for their precision in biomedical sensing, to measure changes in cellular environments. By employing these nano-scale materials, the project promises to provide critical insights into temperature modulation’s effects on neuronal pain pathways and stroke recovery.
Hypothesis:
The research hypothesises that semiconductor quantum dots can be effectively used for in-vitro metrology in neuronal cells, focusing on temperature regulation and pain pathway analysis. This involves developing a novel method to study post-stroke pain mechanisms and nano-thermometry for real-time cellular-level temperature measurement.
Aims and Objectives:
- Utilise semiconductor quantum dots for in-vitro metrology to understand temperature effects on neuronal pain pathways and stroke recovery.
- Develop and optimise quantum dot deposition for creating innovative neuronal cell sensors.
- Analyse sensor responses to pain markers and temperature variations, focusing on fluorescence emission signature.
- Assess sensors’ in-vitro response to pain markers under varying thermal conditions.
Impact:
This project stands at the forefront of neuroscience, integrating metrology and sensor development to enhance our understanding of neuronal adaptive behaviours and recovery processes. It aims to contribute significantly to stroke therapy and pain management strategies.
Academic Requirements:
Applicants should have, or expect to achieve, at least a 2:1 Bachelor’s/Master’s Honours degree in Neuroscience, Electronic Engineering, Biomedical Engineering, Cell Biology, Molecular Biology, Neurology, Physiology or a closely related discipline. The candidate is not expected to have any previous experience within the work described within this project.
Application and enquires:
Interviews are likely to be held between 4 – 15 March. Students must be able to start by October 2024.
Applications are open to students from both the UK and overseas. We anticipate competition for these studentships to be very intense. We would expect applicants to have an excellent undergraduate degree in a relevant discipline. We would also expect applicants to have completed or be undertaking a relevant master’s degree to a similar very high standard (or have equivalent research experience).
Interested candidates are strongly encouraged to contact the project supervisors to discuss their interest in and suitability for the project prior to submitting their application.
Please ensure you pick the Department/Division of Neuroscience when filling in your application form, regardless of where your first supervisor sits.
Funding Notes
University-funded scholarships are for 3.5 years, including home fees, stipend at UKRI rates, and up to £3K per year for consumables/RTSG.
