Call for application n° IC_011_2024_TS – Therapeutic opportunities in Lafora Disease, a rare juvenile neurodegenerative epilepsy with no treatment PRIN 2022 2022WHPWAL

Organisation/Company

CNR – ISTITUTO DI CRISTALLOGRAFIA (IC)

Research Field

Biological sciences

Researcher Profile

First Stage Researcher (R1)

Country

Italy

Application Deadline

11 Mar 2024 – 12:00 (Europe/Rome)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

19 Feb 2024

Is the job funded through the EU Research Framework Programme?

European Union / Next Generation EU

Reference Number

Avviso di selezione n° IC_011_2024_TS

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Lafora disease (LD) is a progressive and fatal epilepsy with teenage-onset. It is caused by the accumulation of insoluble polyglucosans in neurons, determined by an increased glycogen production. At the molecular level, genetic alterations cause missing degradation of the PTG protein; knockout models validate PTG as a therapeutic target in Lafora disease. We aim at identifying small molecules halting and possibly reversing the course of Lafora disease.

The selected candidate will be involved in a further understanding of the molecular basis of LD by investigating the crystallographic structures of proteins and macromolecular complexes related to LD. During the research activity, the expression and purification of the proteins of interest in LD, as well as their crystallization, are planned. Specific in-cell assays are also planned.

Requirements

Research Field

Biological sciences » Biology

Education Level

Master Degree or equivalent

Languages

ITALIAN

Level

Good

Languages

ENGLISH

Level

Basic

Internal Application form(s) needed
BANDO AR IC_011_2024_TS_CASSETTA_signedProt0053967_19022024.pdf
English
(962.88 KB – PDF)
Download
Additional Information
Selection process

Evaluation of the curriculum vitae and interview

Website for additional job details

https://www.urp.cnr.it/system/files/2024-02/BANDO%20AR%20IC_011_2024_TS_CASSETT…

Work Location(s)

Number of offers available

1

Company/Institute

Consiglio Nazionale delle Ricerche – Istituto di Cristallografia, Sede Secondaria di Trieste

Country

Italy

City

Trieste

Postal Code

34149

Street

c/o Area Science Park – Strada Statale 14 km 163,5

Where to apply

E-mail

[email protected]

Contact

State/Province

Bari

City

Bari

Website

https://www.ic.cnr.it/

Street

Via Giovanni Amendola 122/o

Postal Code

70126

E-Mail

[email protected]

STATUS: EXPIRED