University of Lille
tendersglobal.net
2 Jan 2024
Job Information
- Organisation/Company
- University of Lille
- Research Field
- Chemistry
- Researcher Profile
- First Stage Researcher (R1)
- Country
- France
- Application Deadline
- 1 Feb 2024 – 22:00 (UTC)
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- 4 Mar 2024
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Aim of the research project:
Tuberculosis remains the main killer from a bacterial infection worldwide with more than 1.5 million deaths each year. In addition, cases of multidrug and extensively drug resistant Mycobacterium tuberculosis (M.tb) infections have gradually escalated with more than 450,000 new cases of rifampicin-resistant tuberculosis reported in 2022. In recognition of this global health problem, the WHO has placed tuberculosis at the highest critical global priority of antibiotic-resistant bacteria for the development of new antibiotics.
We have recently discovered a new family of inhibitors of mycobacterial Ndh-2 with a unique TricyclicSpiroLactam (TriSLa) scaffold displaying a structural complexity inspired from natural products. These TriSLa molecules have been optimized to sub-micromolar inhibitors of Ndh-2 with time-dependent bactericidal activity on replicating and non-replicating M.tb in vitro and were also demonstrated to be efficacious in an in vivo model of zebrafish (Dam, S. et al., J. Med. Chem. 2022, 65, 24, 16651–16664).
The DONT-TB project was recently funded by Région Hauts de France and the “Initiative d’excellence program” from University of Lille to further optimise this chemical series and identify an optimized preclinical candidate in the TriSLa family for the treatment of tuberculosis.
The project is carried out in collaboration with biologists from the Institute Pasteur of Lille (CBA team, Center for Infection and Immunity of Lille), from Sciensano (Bruxelles, Belgium) and from Sorbonne University (Paris).
Mission:
The candidate will be responsible for developing and optimising the chemical series identified. The candidate’s work will include the design of new analogues, the designed of corresponding synthetic routes, the synthesis and characterization of the analogues and the interpretation of biological data.
In addition, the candidate will participate in meetings with the collaborators to present the work carried out. The candidate will have access to the following techniques: solution and solid phase synthesis, single or parallel synthesis, microwave chemistry, automated preparative HPLC, automated flash chromatography, NMR analysis, LC-MS analysis, chemoinformatics (pipeline pilot, MOE, Pymol, etc).
Requirements
Specific Requirements
We are seeking a candidate with a PhD in organic chemistry or medicinal chemistry. He/she will have a strong experience in multi-step synthesis and will be familiar with LC-MS, 1D and 2D NMR.
A good knowledge of IT tools (bibliographic databases (Reaxys, SCiFinder, PubMed), NMR spectra processing) is important.
A good level of written and spoken english is also expected. It is essential that the candidate is able to work efficiently in the context of an international collaboration and interact with biologists. The candidate should demonstrate rigor, creativity, initiative, and excellent team work.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- University of Lille
- Country
- France
- City
- Lille
- Geofield
Where to apply
- Website
- https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/119198
Contact
- Website
- https://www.deprezlab.fr/
STATUS: EXPIRED
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