CNR - ISTITUTO DI CRISTALLOGRAFIA (IC)
tendersglobal.net
19 Feb 2024
Job Information
- Organisation/Company
- CNR – ISTITUTO DI CRISTALLOGRAFIA (IC)
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Italy
- Application Deadline
- 11 Mar 2024 – 12:00 (Europe/Rome)
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- 19 Feb 2024
- Is the job funded through the EU Research Framework Programme?
- European Union / Next Generation EU
- Reference Number
- Avviso di selezione n° IC_011_2024_TS
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Lafora disease (LD) is a progressive and fatal epilepsy with teenage-onset. It is caused by the accumulation of insoluble polyglucosans in neurons, determined by an increased glycogen production. At the molecular level, genetic alterations cause missing degradation of the PTG protein; knockout models validate PTG as a therapeutic target in Lafora disease. We aim at identifying small molecules halting and possibly reversing the course of Lafora disease.
The selected candidate will be involved in a further understanding of the molecular basis of LD by investigating the crystallographic structures of proteins and macromolecular complexes related to LD. During the research activity, the expression and purification of the proteins of interest in LD, as well as their crystallization, are planned. Specific in-cell assays are also planned.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
- Languages
- ITALIAN
- Level
- Good
- Languages
- ENGLISH
- Level
- Basic
Internal Application form(s) needed
BANDO AR IC_011_2024_TS_CASSETTA_signedProt0053967_19022024.pdf
English
(962.88 KB – PDF)
Download
Additional Information
Selection process
Evaluation of the curriculum vitae and interview
- Website for additional job details
- https://www.urp.cnr.it/system/files/2024-02/BANDO%20AR%20IC_011_2024_TS_CASSETT…
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Consiglio Nazionale delle Ricerche – Istituto di Cristallografia, Sede Secondaria di Trieste
- Country
- Italy
- City
- Trieste
- Postal Code
- 34149
- Street
- c/o Area Science Park – Strada Statale 14 km 163,5
Where to apply
- [email protected]
Contact
- State/Province
- Bari
- City
- Bari
- Website
- https://www.ic.cnr.it/
- Street
- Via Giovanni Amendola 122/o
- Postal Code
- 70126
- [email protected]
STATUS: EXPIRED
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