tendersglobal.net
Offer Description
Lafora disease (LD) is a progressive and fatal epilepsy with teenage-onset. It is caused by the accumulation of insoluble polyglucosans in neurons, determined by an increased glycogen production. At the molecular level, genetic alterations cause missing degradation of the PTG protein; knockout models validate PTG as a therapeutic target in Lafora disease. We aim at identifying small molecules halting and possibly reversing the course of Lafora disease.
The selected candidate will be involved in a further understanding of the molecular basis of LD by investigating the crystallographic structures of proteins and macromolecular complexes related to LD. During the research activity, the expression and purification of the proteins of interest in LD, as well as their crystallization, are planned. Specific in-cell assays are also planned.
Requirements
Internal Application form(s) needed
BANDO AR IC_011_2024_TS_CASSETTA_signedProt0053967_19022024.pdf
English
(962.88 KB – PDF)
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Additional Information
Selection process
Evaluation of the curriculum vitae and interview
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STATUS: EXPIRED
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