Cryo-Electron Microscopy Senior Scientist – Halic Lab

We are looking for an accomplished and enthusiastic researcher to join the Department of Structural Biology as a Senior Scientist to drive new, interdisciplinary research initiatives. The successful candidate will focus on cryo-electron tomography to explore chromatin processes in cells. Expertise in cryo-electron microscopy is required and some experience in cryo-ET is preferred.

The World’s Brightest Minds Always Innovate  

At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. 

The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology approaches. We apply genetics and molecular biology tools to investigate heterochromatin formation in fission yeast and we use cryo-EM to examine chromatin organization and dynamics. While we have focused mainly on single-particle analyses of reconstituted complexes, we aim to use cryo-ET to visualize chromatin processes in their native environment, i.e., inside the nuclear compartment.

More information about the lab and ongoing projects can be found here. Come join us as we embark on the next step of structural biology!

You will be part of a vibrant community at the Department of Structural Biology at St. Jude Children’s Research Hospital, with state-of-the-art facilities that enable integrative structural biology and biophysics investigations — including cryo-EM, X-ray crystallography, biomolecular NMR, single-molecule imaging, protein-protein interactions — combined with computational and data-science approaches. More information about our department can be found here.

Our Cryo-EM Center features a 300keV Titan Krios and a 200keV Talos Arctica electron microscopes, each equipped with K3 direct electron detector and BioQuantum energy filter. A second Titan Krios with Falcon 4i and Selectris X imaging filter is dedicated to cryo-ET projects. The Center was recently upgraded with a Zeiss Crossbeam FIB-SEM and a ThermoScientific Arctis Cryo-Plasma-FIB will be added soon.

In addition, the Center hosts advanced equipment for sample preparation, screening and optimization: ThermoFisher Talos L120C TEM, ThermoFisher Vitrobot Mark IV System, Leica EM GP2 automatic plunge freezer, Gatan Solarus II plasma cleaner, PELCO easiGlow Glow Discharge Cleaning System, and TED PELLA carbon coater 208C. The Center is supported by state-of-the-art computational resources including a dedicated GPU cluster and DDN file storage, and has ready access to the high-performance computing facilities at the St. Jude Data Center.

Minimum Education and/or Training:

• Bachelor’s degree in relevant scientific area is required.
• Graduate degree preferred.

Minimum Experience:

• Ten (10) years relevant post-degree work experience is required with a Bachelor’s degree.
• Eight (8) years of relevant post-degree work experience is required with a Master’s degree.
• Six (6) years of relevant post-degree work experience is required with a PhD.

The World’s Best Stop at Nothing  

There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Glassdoor’s “Best Places to Work” list. Actually, there are more than 5,500 reasons. At our world-class pediatric research hospital, every one of our 5,500 professionals shares our commitment to making a difference in the lives of the children we serve. There’s a unique bond when you are part of a team that will stop at nothing to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where all employees, regardless of their role, receive the resources, support, and encouragement to advance and grow their careers. 

Better at Work. Better at Life. 

When you work at St. Jude, you’ll join a highly collaborative work culture that inspires you every day to be your best.  With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and you’ll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.”   

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. 

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. 

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 – $186,160 per year for the role of Cryo-Electron Microscopy Senior Scientist – Halic Lab.

Explore our exceptional benefits!

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

St. Jude is an Equal Opportunity Employer

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