Investigator in Medicinal Chemistry

Job title:

Investigator in Medicinal Chemistry

Company

GlaxoSmithKline

Job description

The Discovery Chemistry group specialises in the design and development of novel approaches for the synthesis of a range of molecular classes, including antibody drug conjugates, to accelerate drug discovery. The team brings together medicinal chemistry, synthetic organic chemistry and automation skills and experience to deliver medicines of the future, uniting science, technology, and talent to get ahead of disease together.We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageIn this role you will

• Carry out experimental work within the Discovery Chemistry group. This will involve designing and executing synthetic plans to deliver small quantities of antibody drug conjugates for biological evaluation. In addition to the laboratory component of this role, this will also involve analysing data, and designing compounds to test medicinal chemistry hypotheses. In contrast to using synthetic organic chemistry to discover new reactions or methodology, this role will involve applying synthesis to discover compounds with improved biological activity.
• Develop and implement strategies for efficient and high-quality synthesis, purification, and characterisation of antibody drug conjugates.
• Stay up to date with the latest advancements in chemistry and technologies aligned to the group remit and evaluate their potential applications in the discovery of therapeutics.
• Be committed to personal professional development.

Why you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:

• Very good degree or equivalent in chemistry and a PhD/DPhil in medicinal chemistry/synthetic chemistry/chemical biology/Antibody Drug Conjugates.
• Significant and varied experiences working in an Antibody Drug Conjugate professional research environment(s); such as design, synthesis, characterisation or functional testing of Antibody Drug Conjugates.
• A sound understanding of practical organic chemistry and current synthetic methodology is an essential requirement as shown by an extensive track record of high synthetic productivity, route design and problem solving.
• Ability to understand, interpret and communicate complex scientific data.
• Excellent written and oral communication skills enabling efficient presentation of scientific findings to both technical and non-technical audiences.
• Track record of peer reviewed publications. A record of presenting at scientific meetings is also expected.

Preferred Qualifications & Skills:Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Experience of synthesising and handling highly potent Antibody Drug Conjugate payloads, understanding of the containment and safety protocols required for working with cytotoxic compounds.
• Experience of designing, synthesising, and characterising Antibody Drug Conjugate linkers.
• Experience of the conjugation of antibodies to small molecule payloads, including isolation, purification, and characterisation. Experience of conducting sterile workflows is also desired.
• Good understanding of the antibody discovery process

Closing Date for Applications – 21 August 2024 (COB).Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Fri, 26 Jul 2024 00:47:03 GMT

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