PhD Candidate in the Neurophysiological Foundations of Autism Spectrum Disorders

Autism spectrum disorder (ASD) refers to a range of early-onset communication deficits and repetitive sensory-motor behaviors that have a strong genetic component. According to global estimates, ASD affects around 1% of the general population worldwide. Despite the advances in the understanding of ASD clinical symptomatology and causes, the underlying physiological mechanisms remain unknown. This knowledge gap hinders the development of effective biomarkers and therapies for ASD. 

The Cognitive & Systems Neuroscience (CSN) group , part of the Swammerdam Institute for Life Sciences, is looking for a highly qualified and motivated candidate for a doctoral position in Systems Neuroscience to help us unravel these unexplored mechanisms. The position is supported by a recently acquired FLAG-ERA Joint Transnational Call project proposal MONAD (IMpaired cOordiNation between cortical areas as a key to diagnose Autism spectrum Disorders), and coordinated by Dr. Conrado Bosman and Dr. Umberto Olcese. 

This project is part of a larger consortium aiming to unveil basic neuronal network deficits in ASD combining a cross-species translational approach (including mice and humans) with a novel computational framework. We aim to understand how an imbalance in interneuron activity disrupts the coordination between brain regions, potentially causing sensory processing impairments—a key feature of ASD. Using innovative analytical tools, we’ll analyze existing datasets from recordings done in both wild type animals and a mouse model of ASD. This unique approach allows us to explore our hypothesis across different scales, from micro to macro, linking neural mechanisms to clinically relevant measures.

Are you fascinated by the ways the brain orchestrated information and communication transfer across wide areas, and intrigued by how brain dysfunctions triggers the onset of neuropsychiatric disorders like ASD? Then, this job is for you! 

What are you going to do? 

You are expected to:
•    to complete a PhD thesis within the official appointment duration of four years;
•    analyze an existing dataset of multi-area electrophysiological recordings with single-cell resolution in a

     mouse model of autism;
•    develop analytical methods to test the hypothesis that impaired inter-areal coordination correlates with

     sensory processing deficits in ASD;
•    assist during in-vivo multi-area electrophysiological recordings and optogenetics;
•    take part in the teaching effort of the group, including supervision of bachelor’s and master’s students;
•    write scientific manuscripts and a PhD thesis.

What do we require? 

•    a MSc in Neuroscience or a closely related field; a MSc in mathematics, physics, engineering

     or related topics is also possible if the candidate can demonstrate sufficient background in neuroscience;
•    strong scientific expertise in signal processing, brain data analysis and/or behavioral testing;
•    demonstrable experience in complex electrophysiological data analysis;
•    strong programming skills in MATLAB or Python;
•    experience or at least affinity with in in vivo electrophysiology and possession of an “article 9”

     (FELASA B) license are important assets for this position;
•    fluent in English, both written and spoken.

Our offer 

We offer a temporary contract for 38 hours per week, preferably starting on 1 June 2024, for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.  

Based on a full-time appointment (38 hours per week) the gross monthly salary will range from € 2.770 in the first year to € 3.539 (scale P) in the last year. This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable. 

Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here .

About the Faculty of Science and the Swammerdam Institute for Life Sciences  

The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain. 

The Swammerdam Institute for Life Sciences (SILS) is one of the Faculty of Science’s largest institutes. Its approximately 240 scientists and staff members work in 19 research groups that perform excellent research centered on four themes: Neurosciences, Cell & Systems Biology, Microbiology and Green Life Sciences.

Questions?

Do you have questions about this vacancy? Or do you want to know more about our organisation?

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Application

Do you recognize yourself in the job profile? Then we look forward to receiving your application by 31 March 2024. You can apply online by using the link below.  

Applications in .pdf should include:
•    a detailed CV including the months (not just years) when referring to your education and work experience;
•    a letter of motivation;
•    the names and email addresses of two referees who can provide letters of recommendation.

A knowledge security check can be part of the selection procedure.
(for details: National knowledge security guidelines )

The UvA is an equal-opportunity employer. We prioritize diversity and are committed to creating an inclusive environment for everyone. We value a spirit of enquiry and perseverance, provide the space to keep asking questions, and promote a culture of curiosity and creativity.