tendersglobal.net
We are looking for an ambitious PhD student with a broad interest in interdisciplinary research working in the exciting field of Neuroscience.
Project
While most genes associated with neurodevelopmental disorders (NDD) encode proteins involved in transcriptional/epigenetic regulation or synaptic function, increasing evidence suggests that mitochondria dynamics or function may be affected in at least some of these conditions.
Among NDD potentially linked to mitochondria are Rett syndrome (RTT) and MECP2 duplication syndrome, both caused by abnormal dosage of MECP2 protein. We have developed a xenotransplantation model for both disorders, as well as novel ways to investigate the mitochondrial phenotypes in human diseased neurons (Nageshappa et al. Mol Psychiatry. (2016);21(2):178-88; Linaro et al. Neuron (2019) 104(5):972-986; Iwata et al. Science (2023) 379: 1-9 science.abn4705). Here we will explore whether and how mitochondrial abnormalities contribute to the neurological pathology in human neurons in vitro and in vivo. This project will lead to novel insights into NDD mechanisms and potentially to innovative therapeutic venues.
Profile
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How to apply?
Please use the VIB HR Application tool.
Additional required information:
For more information or informal inquiry please contact:
Prof. Dr. Hilde Van Esch, Department of Human Genetics, KULeuven, Laboratory for the Genetic of Cognition, [email protected]
Prof. Dr. Pierre Vanderhaeghen, VIB KULeuven Center for Brain and Disease Research, Stem Cell and Developmental Neurobiology Lab (https://pvdhlab.org ), [email protected]
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