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Offer Description
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented, young scientists the chance to work on cutting edge research projects within the open call on “Molecular Mechanisms in Genome Stability & Gene Regulation”. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.
Activities and responsibilities
The research group of Christof Niehrs offers the following PhD project:
Poly-ADP-ribosylation (PARylation) is a widespread post-translational modification of proteins. In mammalian cells, PARylation is regarded as protein-specific modification. However, we recently discovered that DNA in mammalian cells is PARylated. in mouse embryonic stem cells, mouse heart and muscle, brain, thymus, liver, placenta, and human liver. Furthermore, the modification is reversible by PAR glycohydrolases. We also discovered that DNA PARylation occurs on N1-deoxyadenosine, both in vitro and in vivo. Thus, N1-adenosine PARylation is a novel, reversible DNA modification in mammals (Musheev et al., 2022). This discovery raises many questions regarding the physiological role of DNA PARylation.
PhD project: Role of DNA PARylation in Epigenetic Gene Regulation
In this project, you will examine the role DNA PARylation in mouse embryonic stem cells (mESCs). You will generate and characterize PARylation-defective mutant mESCs by a variety of assays, including standard molecular biology, CRISPR Cas9 gene editing, confocal microscopy as well as Next-Generation-Sequencing. You will learn to analyze these Big Data by bioinformatic analysis. Thereby you will analyze epigenetic profiles in mESCs, to understand the molecular networks involved. You will also characterize PARylation-defective PARP enzymes involving recombinant protein expression and in vitro DNA Parylation.
You will work in a team of cell and molecular biologists and bioinformaticians. The successful candidate will have a strong background in Molecular-or Cell Biology.
If you are interested in this project, please select Niehrs (Nieh) as your group preference in the IPP application platform.
Qualification profile:
Are you an ambitious, young scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start!
All you need is:
We offer
For more details on the projects offered and how to apply via our online form, please visit www.imb.de/phd .
The deadline for applications is 17 April 2024. Interviews will take place at IMB in Mainz on 1-3 July 2024.
Starting date: 1 August 2024 – 1 January 2025
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STATUS: EXPIRED
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