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Background
The Guangzhou Institutes of Biomedicine and Health (GIBH), a research institution affiliated with the Chinese Academy of Sciences (CAS), is situated in Guangzhou, China. As located in the southern region, Guangzhou holds historical, cultural, and economic significance for the country. GIBH strives to implement the “Healthy China” strategy and address public health needs. Its research focuses on investigating pathological mechanisms and developing innovative solutions for disease prevention and control. Furthermore, GIBH offers a world-class core facility and research and development (R&D) platform in the field of biomedicine, and it also serves as a catalyst for global bioengineering and pharmaceutical industries as well as for cutting-edge, strategic-driven research.
GIBH oversees the establishment of Human Cell Lineage Atlas Facility (CLAF), a crucial component of the International Innovation and Technology Hub located in the Guangdong-Hong Kong-Macao Greater Bay Area. The facility’s primary purpose is to facilitate fundamental and applied research in the field of life sciences, with a particular focus on advancing high-tech industries, such as biomedicine and medical instrumentation. By supporting scientific research and fostering innovation in China, CLAF is anticipated to sustain the country’s international prominence and proficiency in life sciences.
CLAF aims to develop the necessary hardware and expertise to establish a worldwide open platform that facilitates cutting-edge scientific and technological advancements. This platform aims to foster cutting-edge scientific and technological advancements in the field of molecular tissue biology at the single-cell level. It aims to incorporate spatial omics data within the analysis of cell types, their developmental trajectories, ageing processes, and pathological conditions. As an open facility, CLAF has the vision of becoming an international hub for academic exchange and collaboration, a centre for talent acquisition and training, and an incubator for industrial innovation.
Position Description
1. Technology Development Post
1.1 Cryobiology
Principal Responsibilities:
1.2 Optical Imaging Technology
Principal Responsibilities:
1.3 Automation Development
Principal Responsibilities:
1.4 Microfluidics and MEMS
Principal Responsibilities:
1.5 Image Processing
Principal Responsibilities:
1.6 Bioinformatics – Causal Inference Based on multi-omics data
Principal Responsibilities:
1.7 Cell Lineage Tracing
Principal Responsibilities:
1.8 Lung Stem Cell and Regeneration
Principal Responsibilities:
2. Biological Application Post
2.1 Tumour Biology
Using lineage analysis and multi-omics techniques to discover new mechanisms and confirm new targets for malignant tumors such as lung cancer and prostate cancer, and develop new strategies for combined therapy.
2.2 mRNA Technology
Develop novel RNA sequence modular construction and cyclization techniques; Build core technology system for mRNA optimization design, targeted delivery, and independent production of raw materials, providing support for the development of RNA based vaccines, drugs, and gene editing strategies, and offering new strategies for cell therapy.
2.3 Virology
Based on existing therapeutic vaccines, candidate drugs, and animal models, analyze the interaction between the virus and host cell interface, discover new targets, design and screen candidate drugs, and develop therapeutic vaccines and new strategies for virus therapy using synthetic biology and other methods.
2.4 New Antibody Technology
Building new antibody (Rabbit, sheep) development technologies and platforms to provide a foundation for drug research and cell therapy.
2.5 Immunology
Based on classical immunology, to study the immunological mechanisms involved in tumor development and treatment, explore new methods of immune tolerance in immune cell therapy, and develop new technologies to avoid immune rejection by donor cells.
2.6 Gene-editing Technology
By utilizing technologies such as human pluripotent stem cell differentiation and small molecule induced reprogramming, safe and efficient gene manipulation techniques are established for diseases such as tumors and gene functional defects, achieving functional upgrades and modifications of therapeutic cells, and constructing a precise therapeutic cell acquisition technology system and specifications.
2.7 Targeted Delivery Technology
Constructing a secure and efficient targeted library of protonated lipid molecules targeting immune cells, stem cells, and tumor tissues with independent intellectual property rights, exploring the molecular structure and targeted delivery structure-activity relationship.
Applicants must meet the following requirements:
Requirements:
Benefits
We offer a competitive salary and generous benefits, access to a first-class scientific research equipment platform, settling-in allowances, and start-up funds for scientific research. Additionally, we recognise the qualifications of our personnel as doctoral supervisors and provide preferential support for graduate enrollment. We also encourage the recruitment of associate researchers/postdoctoral fellows and have ample postdoctoral recruitment quotas available. The details of these benefits are negotiable.
The application must include the following documents:
Contact Us
For Technology Development Post: Ms. Dai He – Tel: +86 (020) 32015214, Email: he_dai@gibh.ac.cn
For Biological Application Post: Ms. He Chen and Ms. Jing Gu – Tel: +86 (020) 32015250, 32015281, Email: chen_he@gibh.ac.cn
Address: 190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou, China
Website: www.gibh.ac.cn
Apply now
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