Postdoctoral Fellow in Liver Disease and Cancer Research (ref. PD/24/01)

15 Jan 2024
Job Information

Organisation/Company

IRB Barcelona

Research Field

Biological sciences » Other

Researcher Profile

Recognised Researcher (R2)

Country

Spain

Application Deadline

5 Feb 2024 – 00:00 (Europe/Madrid)

Type of Contract

To be defined

Job Status

Full-time

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

Yes

Offer Description

IRB Barcelona is seeking a Postdoctoral Fellow to join the laboratory of Raúl Méndez  to participate in a cutting-edge research project funded by the AECC (Spanish Association Against Cancer).

The project will be developed in collaboration with the laboratories of Mercedes Fernandez (IDIBAPS , Barcelona) and Salvador Aznar-Benitah  (IRB Barcelona), with external support from Jonel Trebicka (Münster University, Germany).

The project focuses on understanding the intricate mechanisms leading to the loss of the liver’s stress response mechanism following dietary fat consumption. Our research team has identified key signaling factors in this process and is actively working on developing therapeutic strategies to modulate their activity. The goal is to restore the liver’s stress-coping abilities, eliminate epigenetic memory associated with parental fat consumption, and develop innovative therapies for liver cancer in an aging population with high dietary fat intake.

The project focuses on understanding the intricate mechanisms leading to the loss of the liver’s stress response mechanism following dietary fat consumption. Our research team has identified key signaling factors in this process and is actively working on developing therapeutic strategies to modulate their activity. The goal is to restore the liver’s stress-coping abilities, eliminate epigenetic memory associated with parental fat consumption, and develop innovative therapies for liver cancer in an aging population with high dietary fat intake.

This is a unique opportunity to contribute to groundbreaking research in a vibrant and collaborative scientific community. We are seeking a dynamic and accomplished individual to contribute to translational research at the intersection of liver disease and cancer. Join us in making a meaningful impact on liver disease and cancer research.

Immediate incorporation is possible/desirable.

 

Relevant publications for the project 

1. Bava, FA., Eliscovich, C., Ferreira, PG., Miñana, B., Ben-Dov, C., Guigó, R., Valcárcel, J. and Méndez, R.  “CPEB1 coordinates alternative 3’UTR formation with translational regulation”. Nature, 495(7439):121-125 (2013).

2. Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Navarro P, Bosch J, Fernandez M*, Mendez R*. “Sequential functions of CPEB1 and CPEB4 regulate VEGF expression and angiogenesis in chronic liver disease”. Gastroenterology. 150(4): 982-997.e30 (2016)

3. Carlos Maillo, Judit Martín, Maribel Hernández, David Sebastián, Mar García-Rocha, Antonio Zorzano, Mercedes Fernandez*, Raúl Méndez*. “Circadian and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress” Nature Cell Biology. 19, 94–105 (2017).

4. Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA*, Sassone-Corsi P* Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 2017 Aug 10;170(4):664-677.

5. Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, Samad M, Chen S, Magnan CN, Kinchen JM, Li W, Baldi P, Benitah SA*, Sassone-Corsi P*.Defining the Independence of the Liver Circadian Clock. Cell. 2019 May 30;177(6):1448-1462

6. Greco CM, Koronowski KB, Smith JG, Shi J, Kunderfranco P, Carriero R, Chen S, Samad M, Welz PS, Zinna VM, Mortimer T, Chun SK, Shimaji K, Sato T, Petrus P, Kumar A, Vaca-Dempere M, Deryagin O, Van C, Kuhn JMM, Lutter D, Seldin MM, Masri S, Li W, Baldi P, Dyar KA, Muñoz-Cánoves P, Benitah SA*, Sassone-Corsi P* Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms. Sci Adv. 2021 Sep 24;7(39)

7. Marcos Fernández-Alfara, Annarita Sibilio, Judit Martin, Elsa Tusquets Uxó, Marina Malumbres, Victor Alcalde, Veronica Chanes, Adrià Cañellas, Sergio Palomo-Ponce, Eduard Batlle and Raúl Méndez.“Antitumor T cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress“ EMBO Journal e111494 (2023)

8. Smith JG, Koronowski KB, Mortimer T, Sato T, Greco CM, Petrus P, Verlande A, Chen S, Samad M, Deyneka E, Mathur L, Blazev R, Molendijk J, Kumar A, Deryagin O, Vaca-Dempere M, Sica V, Liu P, Orlando V, Parker BL, Baldi P, Welz PS, Jang C, Masri S, Benitah SA, Muñoz-Cánoves P, Sassone-Corsi PLiver and muscle circadian clocks cooperate to support glucose tolerance in mice. Cell Rep. 2023 Jun 27;42(6):112588.

 

DUTIES: 

• Conduct in-depth research using last-generation multi-omic analyses, including epigenome, epitranscriptome, translatome, metabolome, etc.

• Conduct research using genetically modified mouse models of disease and analyze patient samples.
• Independently design and test biological hypotheses.
• Collaborate with a multidisciplinary research team, tapping into the expertise of fellow researchers and external collaborators.
• Contribute to a culture of scientific excellence, efficiency, and teamwork.

 

EXPERIENCE, KNOWLEDGE, SKILLS:

Must Have – Required: 

• PhD in a relevant field.
• Experience in conceptual or technical aspects related to the project.
• Strong background in liver biology, cancer, or related fields.
• Demonstrated ability to design and conduct experiments independently.
• Excellent communication skills and the ability to collaborate effectively.

 

WORKING CONDITIONS & ENTITLEMENTS:

• Working conditions: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leaves and injuries at work.
• Training and Career: Postdoctoral researchers joining IRB Barcelona gain access to the Institute’s advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute.
• Estimated annual gross salary: Salary commensurate with experience and qualifications.
• International environment: Nearly 90 Postdoctoral researchers (more than a half non-Spanish nationals) are currently working at IRB Barcelona.

Requirements

Research Field

Biological sciences » Other

Education Level

PhD or equivalent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

IRB Barcelona

Country

Spain

Geofield

Where to apply

Website

https://recruitment.irbbarcelona.org/jobs/3514806-postdoctoral-fellow-in-liver-…

Contact

City

Barcelona

Website

http://www.irbbarcelona.org/index.php/en

Street

Baldiri Reixac, 10

Postal Code

08028

E-Mail

[email protected]

STATUS: EXPIRED