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Postdoctoral Fellow – Thoracic and Head &Neck Medical Oncology – KRAS-mutant non-small cell lung cancer (NSCLC)
Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested in understanding the molecular diversity of KRAS-mutant NSCLC and developing rational and tailored treatment strategies for patients bearing KRAS-mutant lung tumors. We utilize a multifaceted approach that encompasses preclinical studies in immune competent syngeneic and genetically engineered co-mutational models of KRAS– mutant NSCLC as well as PDX/CDXs, in vitro models and large collections of well annotated clinical specimens. We employ state of the art computational biology/bioinformatics approaches to dissect acute and adaptive responses to RAS inhibition in vitro and in vivo. We are committed to a question-driven approach that seeks to address the most urgent clinically relevant scientific questions. Applicants with experience in any of these areas and a true passion for cutting-edge bench to bedside research are encouraged to apply and provide three professional references.
LEARNING OBJECTIVES
Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas technology, Western blotting, ELISA, immunohistochemistry), in vitro assays (such as drug screening, flow cytometry, development of resistant cell lines) and in vivo experiments using xenograft, syngeneic and genetically engineered mouse models of KRAS-mutant lung cancer. Candidates with prior experience in computational biology will acquire additional skills and be involved in the analysis of single cell RNA Sequencing, WES and in situ transcriptomics data. Trainees will present their findings at regular lab meetings, departmental seminars, and national conferences. Trainees will submit their findings for publication in peer-reviewed scientific journals.
Eligibility Requirements
Applications are invited from qualified individuals interested in working in a translational research lab; with a PhD and/or MD. The ideal candidate(s) should have less than 2 years of prior postdoctoral experience and have a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting and studies involving mouse models of KRAS-driven cancers is preferred. We are also looking for applicants with prior expertise in computational biology and bioinformatics including analysis of single cell RNA sequencing data and in situ transciptomics. Candidates should be innovative thinkers and highly motivated to pursue an independent career in biomedical research.
Job Knowledge And Skills
POSITION INFORMATION
MD Anderson follows the NIH stipend levels as outlined by the “Kirchstein – NRSA”. This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.
MD Anderson offers compensated trainees:
FACULTY MENTOR
Ferdinandos Skoulidis, MD, PhD
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