Postdoctoral Research Associate – Bone Marrow Transplant & Cellular Therapy

A postdoctoral research associate position is available in the lab of Dr. Senthil Bhoopalan.

Project Description:
Bone marrow failure (BMF) disorders are catastrophic diseases of childhood that result in failure to produce hematopoietic cells leading to severe morbidity and eventually mortality. Treatment options are limited to lack of appropriate model systems. The Bhoopalan lab has pioneered the use of CRISPR/Cas9 and base editors to model rare BMF disorders to gain insights into these rare blood disorders. Furthermore, we are leveraging this system and the generated knowledge to develop cell-based therapies for rare and ultrarare bone marrow failure disorders. This translational project will lead to development of novel disease models and gene therapies for BMF disorders.

Position Responsibilities:
1. Develop novel research project(s) and idea(s) in collaboration with mentor
2. Design and perform experiments, interpret data, and communicate results with scientific community
3. Work with mice models of human disease
4. Work collaboratively with a multidisciplinary team and with collaborative labs inside and outside St. Jude
5. Generate initial draft for grants and research manuscripts
6. Any professional development requirement, including grant writing

Minimum Education and/or Training:
PhD

Special Skills, Knowledge, and Abilities:
¬
– Experience working with mice
– Strong background in cell biology and HSC biology
– Exposure to high-throughput screens, CRISPR/Cas9, base editors will strengthen the application

About the lab and St. Jude:
The Bhoopalan lab’s goal is to advance our mechanistic understanding of human hematopoiesis in health and disease and leverage these findings to develop curative therapies for human blood disorders. The Bhoopalan lab is a diverse multidisciplinary group that utilizes various tools from molecular biology, cell biology, computational data science and translational medicine. Trainees will have access to the deep technical expertise in the lab, and the opportunities to participate in wide range of collaborative efforts, lead projects, learn grantsmanship and develop a path towards independent research.

St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work,” and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture.

We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress. Other than access to top-quality scientists and mentors, as a postdoctoral trainee at St. Jude, you will have:
• A Blend of Academic Freedom and Industrial Efficiency: Access to shared resources and facilities led by expert scientists, coupled with cutting-edge technology, accelerates research productivity.
• Customized Professional and Career Growth: Experience specifically designed programs to enhance professional growth and career readiness empowering postdocs for success beyond their training. This includes access to grant writing workshops, individual development plans, teaching and mentoring opportunities, non-research career advancement programs, professional development allowance, and so much more.
• Competitive Compensation: Embark on your journey with a competitive salary starting at $70,000 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent.
• A Sense of Community: St. Jude fosters a vibrant postdoc community that supports a well-balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds.

Bone marrow failure (BMF) disorders are catastrophic diseases of childhood that result in failure to produce hematopoietic cells leading to severe morbidity and eventually mortality. Treatment options are limited to lack of appropriate model systems. The Bhoopalan lab has pioneered the use of CRISPR/Cas9 and base editors to model rare BMF disorders to gain insights into these rare blood disorders. Furthermore, we are leveraging this system and the generated knowledge to develop cell-based therapies for rare and ultrarare bone marrow failure disorders. This translational project will lead to development of novel disease models and gene therapies for BMF disorders.

Position Responsibilities:

Develop novel research project(s) and idea(s) in collaboration with mentor Design and perform experiments, interpret data, and communicate results with scientific community Work with mice models of human disease Work collaboratively with a multidisciplinary team and with collaborative labs inside and outside St. Jude Generate initial draft for grants and research manuscripts Any professional development requirement, including grant writing

Minimum Education and/or Training:

PhD

Special Skills, Knowledge, and Abilities:

­

• Experience working with mice

• Strong background in cell biology and HSC biology

• Exposure to high-throughput screens, CRISPR/Cas9, base editors will strengthen the application

About the lab and St. Jude:

The Bhoopalan lab’s goal is to advance our mechanistic understanding of human hematopoiesis in health and disease and leverage these findings to develop curative therapies for human blood disorders. The Bhoopalan lab is a diverse multidisciplinary group that utilizes various tools from molecular biology, cell biology, computational data science and translational medicine. Trainees will have access to the deep technical expertise in the lab, and the opportunities to participate in wide range of collaborative efforts, lead projects, learn grantsmanship and develop a path towards independent research.

St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work,” and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture.

We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress. Other than access to top-quality scientists and mentors, as a postdoctoral trainee at St. Jude, you will have:

• A Blend of Academic Freedom and Industrial Efficiency: Access to shared resources and facilities led by expert scientists, coupled with cutting-edge technology, accelerates research productivity.

• Customized Professional and Career Growth: Experience specifically designed programs to enhance professional growth and career readiness empowering postdocs for success beyond their training. This includes access to grant writing workshops, individual development plans, teaching and mentoring opportunities, non-research career advancement programs, professional development allowance, and so much more.

• Competitive Compensation: Embark on your journey with a competitive salary starting at $72,500 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent.

• A Sense of Community: St. Jude fosters a vibrant postdoc community that supports a well-balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds.

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

St. Jude is an Equal Opportunity Employer

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