Postdoctoral Research Scientist – Xenotransplantation

Position Description

At the Stavros Niarchos Foundation (SNF) Center for Precision Psychiatry & Mental Health, we envision a time in the near future when mental illness is treated in novel, targeted, and tailored ways, based on an understanding of disease etiology and pathophysiology. Our mission is to apply advances in neuroscience, technology and precision medicine to psychiatry. The SNF Center is dedicated to identifying scientific breakthroughs that further our understanding of the biological causes and underpinnings of mental illness. By addressing biological causes, and identifying genetic and other biological markers, the SNF Center aims to contribute to reduce the stigma of mental illnesses and address societal disparities by ensuring equitable access to breakthrough Precision Psychiatry treatments.

The Postdoctoral Research Scientist will be responsible for establishing and leading a research program located within the Zuckerman Mind Brain and Behavior Institute involving mouse brain xenotransplantion of human induced Pluripotent Stem Cell (hiPSC)-derived neurons, to model psychiatric diseases with the ultimate goal to facilitate translational efforts and develop new targeted treatments. Methods include hiPSC-based culture, cutting edge in vivo imaging and electrophysiology in awake behaving mice to analyze neural structure and activity patterns, as well as cellular and molecular characterization of engrafted hiPSC-derived neurons. Successful candidates will have opportunities to interact and collaborate with researchers and research platforms at the Institute as well as across Columbia’s top-tier stem cell and neuroscience community.

The Zuckerman Institute’s home, the Jerome L. Greene Science Center is a state-of-the-art facility on Columbia’s Manhattanville campus. Situated in the heart of Manhattan in New York City, the Zuckerman Institute houses over 50 laboratories employing a broad range of interdisciplinary and diverse approaches to transform our understanding of the mind and brain. In this highly collaborative and inclusive environment, experimental, computational, and theoretical labs work together to gain critical insights into how the brain develops, performs, endures and recovers.

Duties involve the following tasks:

Conduct laboratory research in translational neuroscience projects Design and perform experiments; collect and analyze data Prepare manuscripts for publication in peer-reviewed journals Engage in scientific communication at conferences and training of junior lab members Qualifications

Minimum Degree Required

Ph.D. or equivalent doctoral degree in neuroscience or related fields, have a strong publication record and demonstrated experience in two-photon imaging or neural activity analysis in mouse brain. Minimum Qualifications

Strong computational skills, including programming in MATLAB or Python are highly desirable. Experience in iPSC-based methods for neuroscience is desirable but not required. Candidates with superior motivation, drive and demonstrated aptitude for carrying out independent research, as well as experience and interest in training and mentoring team members, are encouraged to apply.

Application Instructions

Candidates should submit their application, including a curriculum vitae, a brief cover letter outlining their research interests and goals, and the contact information of three individuals who will provide letters of reference. Informal inquiries are also welcome.