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Offer Description
i3s – Institute for Research and Innovation in Health (hereinafter i3) is opening a call to award a grant for the development of R&D activities by Master´s enrolled in non-academic degree courses integrated into the educational project of a higher education institution, within the project “ The role of the heme-exporter FLVCR1 in hepatocellular carcinoma”, Ref. – 2022.03222.PTDC, financed by national funds through FCT – Fundação para a Ciência e a Tecnologia, I.P.
Host Institution: i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Scientific Area: Oncology.
Project Title: “The role of the heme-exporter FLVCR1 in hepatocellular carcinoma”.
Workplans:
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the third leading cause of cancer-related deaths worldwide. There is an unmet need to discover new biological mechanisms in HCC and develop new therapies. The FLVCR1 protein is the only known exporter of heme, a precursor to haemoglobin and other crucial hemoproteins that is biosynthesized in the bone marrow and liver. It was recently reported that FLVCR1 expression is increased in HCC, positively correlated with vascular invasion and associated with worse survival. However, the role of FLVCR1 in HCC remains unexplored. We hypothesize that FLVCR1 has a pro-tumorigenic role in HCC. In the current project we propose to comprehensively dissect the role of FLVCR1 in HCC using patient samples, human HCC cell lines and well-established mouse models of HCC. This research has potential translational implications for biomarker discovery and drug development in liver cancer.
Admission Requirements:
Mandatory Admission Criteria : Master’s Degree in areas related to the project, including but not restricted to Biology, Molecular Biology, Biochemistry, Medicine, Oncology, and Bioengineering. Candidates must also be enrolled in a non-academic degree course integrated into the educational project of a higher education institution, at the time of the start of the contract.
Essential Selection Criteria:
– Experienced with animal (murine) research models;
– Experienced with human cell culture;
Preferential :
– Demonstrated research experience in oncology;
– Extensive hands-on expertise with immunohistochemistry;
– Holder of FELASA B (or equivalent) and/or DGAV certification for performing animal research;
– Fluent in English language (spoken and written).
Legislation and other applicable regulations: Research Fellowship Holder Statute enacted by Law no. 40/2004 of August 18th, as amended; FCT Research Grants Regulation, approved by way of Regulation nr. 950/2019, published in the II Series of DR of December 16th, 2019; i3S Research Grants Regulation.
Place: The research activities will be hosted at i3S, under the scientific coordination of Doctor Tiago L Duarte.
Length time: The initial duration of the fellowship is 4 months. The expected starting date is march 1st , 2024, upon availability of the financed funds.
Monthly maintenance stipend: €1.199,64, according to the values table of FCT, at Portugal (https://www.fct.pt/wp-content/uploads/2023/02/Tabela-de-Valores-SMM_2023.pdf ). The payments will be made by bank transference.
Research grants may also include other components, as the voluntary social insurance, under the terms of the Research Fellowship Holder Statute, article 10.
Evaluation Criteria: Candidates will be selected according to the admission requirements:
– Relevant laboratorial experience in the research area of the application. (50%)
– Scientific production, including oral/poster communications and publications. (20%)
B) Motivation letter (20%)
– Interest and motivation for the research area framing the position to be hired (15%)
-Proficiency in English and written communication (5%)
C) Interview (10%)
-Candidates that fulfil all the mandatory selection criteria, and with a rating higher than 70% in A and B (above), will be invited to an interview.
Candidate final classification system shall be given based on a scale 0-100.
Evaluation Panel: President: Tiago L Duarte; Other Members: Delfim Duarte and Graça Porto.
Information and Publicity of Funding Granted: The results of the evaluation will be notified by email to all candidates. After notification, candidates have 10 working days to comment and, within that period, a complaint may be submitted by email to [email protected] .
Applications: The call will be open between January 19th 2024 to February 2st 2024. The applications must be submitted electronically at:
https://dozer.i3s.up.pt/applicationmanagement/#/addapplications/6288b17edee026657452d375b23dad98
The required documents composing the applications are: Certificate of Qualifications, Curriculum Vitae, letter of motivation, and the contact of at least one referee. The candidate also needs to provide proof of enrolment in a course that does not confer an academic degree (proof of enrollment or a honor statement of capacity to enroll in the aforementioned course until the grant is contracted), and other documents, considered as relevant by the candidate.
Documents to be provided at the time of contracting: in addition to those mentioned in the previous point, it is necessary to present proof of enrollment in non-academic degree course integrated into the educational project of a higher education institution.
Full announcement at: https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/a9144c19e…
Requirements
Specific Requirements
Mandatory Admission Criteria : Master’s Degree in areas related to the project, including but not restricted to Biology, Molecular Biology, Biochemistry, Medicine, Oncology, and Bioengineering. Candidates must also be enrolled in a non-academic degree course integrated into the educational project of a higher education institution, at the time of the start of the contract.
Essential Selection Criteria:
– Experienced with animal (murine) research models;
– Experienced with human cell culture;
Preferential :
– Demonstrated research experience in oncology;
– Extensive hands-on expertise with immunohistochemistry;
– Holder of FELASA B (or equivalent) and/or DGAV certification for performing animal research;
– Fluent in English language (spoken and written).
Additional Information
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