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The Tissue Regeneration and Cancer MSc Research Programme is hosted by the School of Cancer Sciences and aims to deliver high quality research, training and mentorship to excellent and ambitious students interested in cancer research, including but not limited to its intersection with stem cell biology, immunity, metabolism, development, regenerative biology and behavioural science.
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Research projects
Research projects
Assessing the activity of novel compounds in Human Derived Biliary Tract Cancer preclinical models.
Supervisors: Chiara Braconi and Sergi Marco
Project summary: Biliary Tract Cancers (BTC) are tumours arising from the bile duct within and outside the liver. There is an unmet need to develop novel therapeutic strategies that can impact on survival of BTC patients. Here we will test novel compounds in multicellular, patients’ derived, preclinical models to identify the clinical potential of these compounds and define the best strategies for designing their clinical implementation. The candidate will develop skills in cell culturing, with particular reference to 3D models, and molecular biology with the development of stably transfected clones. She/he will also have an opportunity to develop troubleshooting skills and critical thinking. There will be particular attention to the training of the presentations skills with need to present regularly at the lab meeting and possibility to present at international meetings should the candidate be considered appropriately skilled and trained.
Developing CRISPR tools for targeting tumour suppressors in Mesothelioma.
Supervisors: Daniel Murphy and Jennifer Doig
Project summary: Join the world-leading Mesothelioma research laboratory of Prof Daniel J. Murphy to develop new CRISPR tools to investigate the functional role of under-investigated tumour suppressor genes in Mesothelioma. We are the UK’s only laboratory routinely using state of the art in vivo models to investigate this lethal cancer and your contribution could have a meaningful impact on our work. We will help you develop the skills you need to advance your career in an exciting area of cancer research, along with the transferable skill to give you flexibility in your future direction.
The primary aim of this project is to develop and validate CRISPR vectors targeting additional clinically relevant TSGs. Vectors will be designed and subcloned, then tested in cell culture for their ability to accurately disrupt TSG expression. Validated vectors will subsequently be used by Murphy lab personnel in vivo to understand the contribution of each TSG to Mesothelioma development. You will develop arrange of contemporary skills that will strengthen your potential to progress into a PhD programme or professional research laboratory. This will include CRISPR guide RNA design and subcloning, cell culture, recombinant vector production and validation, QPCR and protein immunoblotting. You will also advance your transferable skills including critical thinking, data evaluation & presentation and scientific writing of reports.
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Exploiting mitochondrial inflammatory signals to engage anti-tumour immunity.
Supervisors: Stephen Tait and Danny Huang
Project summary: Cell death prevents and treats cancer. Typically, therapies cause apoptotic cell death of cancer cells. In brief, apoptosis requires mitochondria to activate proteases call caspases. Apoptosis is a silent form of cell death that fails to evoke an immune response. We have found that killing cells under caspase inhibition elicits powerful anti-tumour immunity that can eradicate cancer in experimental models. Underlying this are inflammatory signals sent out by the mitochondria. This project aims to understand the fundamental mechanisms of inflammation triggered by permeabilized mitochondria. It will entail a variety of cutting-edge methods including genome-engineering, high-resolution microscopy and in vivo tumour biology. Using this knowledge our goal is to enhance our ability to effectively kill cancer by engaging anti-tumour immunity.
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Investigating Metabolic changes in PPARG Driven Prostate Cancer
Supervisors: Imran Ahmad and Tom MacVicar
Project summary: There exists a huge degree of prostate cancer cell metabolic remodelling to enable tumours to grow and combat androgen deprivation therapy. The mitochondria are essential organelles that support tumour adaptation, by dynamically reprogramming during tumorigenesis. Previous work in our group has identified the key role of the metabolic regulator PPARG in driving metastatic prostate cancer.
In this project, the candidate will use tumour models including genetically engineered mice to investigate how mitochondria contribute to tumorigenesis and treatment resistance. The candidate will study mitochondrial dynamics in these models with metabolomic and proteomic techniques. These studies will improve our basic understanding of metabolic changes in tumours and may identify novel therapeutic targets for prostate cancer.
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Live imaging cell death and its clearance during tissue remodelling and cancer.
Supervisors: Andrew J. Davidson and Stephen Tait
Project summary: Multi-cellular organisms are not created through cell proliferation alone. During development and tissue remodelling, healthy cells are deliberately removed through cell death in order to sculpt the tissue into its final form. However, if dead cells are not removed quickly through engulfment by other cells (such as macrophages), chronic inflammation is triggered. Therefore, the efficient clearance of cellular debris is vital for our health and wellbeing. Furthermore, in pathologies where cell death is elevated, overwhelmed clearance may exacerbate diseases such as cancer. In this project, we will use live-microscopy and the fruit fly, Drosophila melanogaster, to visualise the clearance of dead cells inside a living organism. Furthermore, we will combine advanced biosensors of cell death, the microinjection of dyes and Drosophila’s unrivalled genetics to investigate the importance of this clearance to development, tissue remodelling and tumourigenesis.
As part of this project, the student will gain extensive experience in live-imaging, including training on a variety of different confocal microscopes. Furthermore, the student will learn genetics, Drosophila husbandry and cell culture, as well as specialist techniques such as microinjection. The student will also receive mentoring on scientific critical thinking and writing. By the end of the project, the student will be well placed for a future career in biomedical sciences.
References
Metabolic adaptations of intestinal stem cells in health and disease.
Supervisors: Julia Cordero and Vignir Helgason
Project summary: Metabolism is a key determinant of cellular phenotype, amenable to nutritional and/or pharmacological therapeutic interventions. Although the impact of diet and metabolism in homeostatic intestinal stem cell (ISC) renewal and differentiation is well documented, the metabolic adaptations of ISCs to tissue injury and their influence on regeneration and cancer are largely unknown. While recent studies on mammalian systems have provided significant insight into ISC metabolism, these rely largely on in vitro cultures. The use of in vivo models is important to account for the influence of the natural microenvironment on ISC metabolism. Research on the adult Drosophila midgut — an organ with remarkable homology to the mammalian small intestine—has provided invaluable knowledge on ISC biology in health and disease. We use the adult Drosophila midgut as a high throughput in vivo paradigm for characterization of metabolic changes in ISCs following tissue damage and their functional role in intestinal regeneration and tumourigenesis. During this project, the student will receive theoretical and practical training in genetics, imaging, metabolism, intestinal biology, tissue regeneration and cancer.
References
Role of INPP4b in PTEN-driven Prostate Cancer
Supervisors: Imran Ahmad and David Bryant
Project summary: The tumour suppressor gene PTEN is one of the most often deleted genes in human prostate cancer. Previous work from our groups have elucidated how PTEN loss, often with co-operating mutations, can drive metastatic prostate cancer. Our recent work, using a forward transposon-based screen, has identified loss of INPP4b co-operating with PTEN loss to drive treatment resistant prostate cancer. In this innovative project, the candidate will use 3D tumour models combined with orthotopic mouse models to investigate how INPP4B loss contributes to prostate tumourigenesis in a PTEN loss background. The candidate will study enzymes involved in phosphatidylinositol signaling pathways, to improve our basic understanding of this pathway in tumours and may identify novel therapeutic targets for prostate cancer.
References
Overview
Overview
Programme description
Students will undergo 1-year of full-time research in a laboratory chosen from our supervisory pool of world-renowned principal investigators. A further year is allowed for thesis writing.
In addition to their research time, students will have the opportunity to participate in research seminars [Glasgow Cancer Seminar Series ], tutorials, science retreats and interactive discussion groups. Bioinformatic, research integrity and data management training courses are also offered to PGR students. Our skills pathway sets out recommended courses at different stages of PGR research study.
Students will have a primary and secondary research supervisor and 2 reviewers, who will oversee annual research progress. Students will give an introductory talk after the initial review panel meeting and within 4 months of starting their research year. At the end of their research year, students will write a MSc by Research thesis report (max 50,000 words) to be assessed by an internal and external examiner. The examiner may require a viva voce. Students will have up to 12 months after their year of laboratory research to fulfil these requirements for degree award.
School of Cancer Science
You will study in state-of-the-art laboratory space at our School of Cancer Sciences . The school provides multiple centralised facilities operated by expert managers. These include tissue culture, flow cytometry, imaging, metabolomic, proteomics, genomics, high content screening, histology facilities and biological service unit.
We bring together world-leading fundamental stem cell, inflammation, cancer and tissue regeneration research with established clinical and discovery research excellence.
The School of Cancer Sciences includes:
Learning outcomes
Towards the end of the programme, students will have been exposed to and acquire a wealth of laboratory research techniques and conceptual learning knowledge. These will include but not be limited to the following:
Technique learning
Conceptual learning
Programme management team
Programme Director: Prof. Julia Cordero , Professor of Systemic Signalling Biology.
The programme is supported by:
Study options
Study options
MSc (Research)
Entry requirements
Entry requirements
A 2.1 Honours degree or equivalent.
To be eligible for the MSc by Research in Tissue Regeneration and Cancer programme you should have a UK 2:1 honour degree, or its international equivalent, in a relevant biological or medical discipline. Candidates will have to meet the standard English language entry requirements of The University of Glasgow. All applicants will be asked to demonstrate a level of English language competency, regardless of their nationality or country of residence.
You must demonstrate a level of English language competency that will enable you to succeed in your studies, regardless of your nationality or country of residence. The University accepts a wide range of international English qualifications and English language tests.
Find out more about English language requirements for the University of Glasgow.
English language requirements
For applicants whose first language is not English, the University sets a minimum English Language proficiency level.
International English Language Testing System (IELTS) Academic module (not General Training)
Common equivalent English language qualifications accepted for entry to this programme:
TOEFL (ibt, my best or athome)
Pearsons PTE Academic
Cambridge Proficiency in English (CPE) and Cambridge Advanced English (CAE)
Oxford English Test
Trinity College Tests
Integrated Skills in English II & III & IV: ISEII Distinction with Distinction in all sub-tests.
University of Glasgow Pre-sessional courses
Tests are accepted for 2 years following date of successful completion.
Alternatives to English Language qualification
For international students, the Home Office has confirmed that the University can choose to use these tests to make its own assessment of English language ability for visa applications to degree level programmes. The University is also able to accept UKVI approved Secure English Language Tests (SELT) but we do not require a specific UKVI SELT for degree level programmes. We therefore still accept any of the English tests listed for admission to this programme.
Pre-sessional courses
The University of Glasgow accepts evidence of the required language level from the English for Academic Study Unit Pre-sessional courses. We also consider other BALEAP accredited pre-sessional courses:
Fees and funding
Fees and funding
Tuition fees
2024/25
Prices are based on the annual fee for full-time study. Fees for part-time study are half the full-time fee.
Irish nationals who are living in the Common Travel Area of the UK, EU nationals with settled or pre-settled status, and Internationals with Indefinite Leave to remain status can also qualify for home fee status.
Alumni discount
We offer a 20% discount to our alumni on all Postgraduate Research and full Postgraduate Taught Masters programmes. This includes University of Glasgow graduates and those who have completed Junior Year Abroad, Exchange programme or International Summer School with us. The discount is applied at registration for students who are not in receipt of another discount or scholarship funded by the University. No additional application is required.
Possible additional fees
Students will be expected to pay a contribution to research running costs. This is in addition to your tuition fees. The value of the contribution is negotiable and will be supplemented by the host laboratory and/or supported by the School of Cancer Sciences eg. for competitive candidates with part (tuition fees only) scholarships or fully self-funded students.
Support
Support
The College of Medical, Veterinary and Life Sciences provides a vibrant, supportive and stimulating environment for all our postgraduate students. We aim to provide excellent support for our postgraduates through dedicated postgraduate convenors, highly trained supervisors and pastoral support for each student.
Our overarching aim is to provide a research training environment that includes:
How to apply
How to apply
Identify potential supervisors
All Postgraduate Research Students are allocated a supervisor who will act as the main source of academic support and research mentoring. You need to identify a project from our programme projects list . And then contact the potential supervisor to discuss your application before you apply. Please note, even if you have spoken to an academic staff member about your application, you still need to submit an online application form.
Gather your documents
Before applying to the MSc by Research Program in Tissue Regeneration and Cancer, gather the following supporting documentation:
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Contact us
Before you apply
MSc (Research): email [email protected]
After you have submitted your application
MSc (Research): contact our Admissions team
Any references may be submitted by email to: [email protected]
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